The 'Petya' ransomware attack has affected companies in countries including the UK, Russia, India, Spain, France, Denmark and Norway.
The radiation monitoring system at Ukraine's Chernobyl nuclear power plant has been hit by the unprecedented security breach.
Britain-based advertising giant WPP is also among dozens of firms reporting issues.
WPP, the world's biggest advertising business, said a number of its companies had been affected and it was currently "assessing the situation".
In a statement, the FTSE 100 firm said: "IT systems in several WPP companies have been affected by a suspected cyber attack.
"We are assessing the situation, taking appropriate measures and will update as soon as possible."
Ukrainian deputy prime minister Pavlo Rozenko said the computer system at the government's headquarters has been shut down.
He added: "It was an unprecedented attack, but our IT experts are doing their work and protecting strategic infrastructure.
"Important systems have not been affected."
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